Nowadays, the model of genetic coding (code of the biosynthesis of proteins), proposed by M. Nirenberg and F. Crick almost 50 years ago, suffers severe erosion. Tactically, it is correct: the organisation in triplets and degeneration of the code expressed in the existence of synonymous codons are evident. But the postulate of Nirenberg–Crick that the coding of amino acids is a singular value, i.e., strategy, raises a reasonable doubt. The reasons for those doubts arose very quickly: It was shown that the triplet UUU simultaneously encodes phenylalanine and leucine, which does not correspond to the declaration of uniqueness of DNA-RNA encoding the amino acids in proteins. On the other hand, the ambiguity of coding came automatically from the postulate of F. Crick about pairing wobble (randomness, not determination) of the third nucleotide in codon. This means that the 3'–5' pair of codones–anticodones are not involved in the coding and are the ‘crutch steric’. In fact, amino acids are encoded not by the treble but by the doublet of nucleotides within the triplet by Ulf Lagerkvist’s ‘two out of three’ rule.